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Rotigotine Hydrochloride

Name: Rotigotine Hydrochloride
Brand: TargetMol
SKU: T21446
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21446Cas No. 125572-93-2

Alias Rotigotine HCl, Rotigotine (Hydrochloride), N-0924, N-0923, N 0923

Rotigotine Hydrochloride (N-0924), a dopamine receptor agonist prefering for D3 receptors over D1 and D2, has effective activity of anti-Parkinsonian. Racemic rotigotine hydrochloride is about 50 times as potent as quinpirole, the gold standard D2 agonist.

Rotigotine Hydrochloride

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Purity: 99.56%

Catalog No. T21446Alias Rotigotine HCl, Rotigotine (Hydrochloride), N-0924, N-0923, N 0923Cas No. 125572-93-2

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$37	In Stock	In Stock
10 mg	$54	In Stock	In Stock
25 mg	$88	In Stock	In Stock
50 mg	$118	In Stock	In Stock
100 mg	$162	In Stock	In Stock
200 mg	$239	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$40	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.56%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	Rotigotine Hydrochloride (N-0924), a dopamine receptor agonist prefering for D3 receptors over D1 and D2, has effective activity of anti-Parkinsonian. Racemic rotigotine hydrochloride is about 50 times as potent as quinpirole, the gold standard D2 agonist.
Targets&IC50	5-HT7 receptor:86 nM (Ki), D5 receptor:4-15 nM (Ki), D4 receptor:4-15 nM (Ki), α1B-adrenoceptor:273 nM (Ki), α2B-adrenoceptor:27 nM (Ki), α2A-adrenoceptor:338 nM (Ki), α1A-adrenoceptor:176 nM (Ki), D3 receptor:0.71 nM (Ki), 5-HT1A receptor:30 nM (Ki), D1 receptor:83 nM (Ki), D2 receptor:4-15 nM (Ki)
Synonyms	Rotigotine HCl, Rotigotine (Hydrochloride), N-0924, N-0923, N 0923

Chemical Properties

Molecular Weight	351.93
Formula	C₁₉H₂₆ClNOS
Cas No.	125572-93-2
Smiles	Cl.CCCN(CCc1cccs1)[C@H]1CCc2c(O)cccc2C1
Relative Density.	1.2 g/cm3 at 20℃

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 70 mg/mL (198.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8415 mL	14.2074 mL	28.4147 mL	142.0737 mL
5 mM	0.5683 mL	2.8415 mL	5.6829 mL	28.4147 mL
10 mM	0.2841 mL	1.4207 mL	2.8415 mL	14.2074 mL
20 mM	0.1421 mL	0.7104 mL	1.4207 mL	7.1037 mL
50 mM	0.0568 mL	0.2841 mL	0.5683 mL	2.8415 mL
100 mM	0.0284 mL	0.1421 mL	0.2841 mL	1.4207 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc